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Grey’s Anatomy is the longest-running medical drama in television history, and it’s about to hit a major milestone. The flagship Shondaland series is about to hit episode 400. And showrunner Krista Vernoff promises “a pretty big event.”

Grey’s Anatomy star Ellen Pompeo smiling in scrubs as Meredith Grey
Ellen Pompeo on ‘Grey’s Anatomy’ | ABC via Getty Images/ Raymond Liu

‘Grey’s Anatomy’ and ‘Station 19’ return with a crossover

Two months after airing their respective winter finales, Grey’s Anatomy and its spinoff Station 19 are returning on February 24 with a major crossover event. In the action-packed teaser, first responders are on the scene when Dr. Owen Hunt’s (Kevin McKidd) car falls off a cliff.

“I am going to get my friend,” Ben (Jason Winston George) says in the snippet. Viewers also hear Sullivan (Boris Kodjoe) say, “Civilian down, no pulse.”

Meanwhile, Meredith (Ellen Pompeo) is in the emergency room trying to save Dr. Hamilton’s (Peter Gallagher) life amid other issues at Grey Sloan Memorial.

Fans are excited for the Shondaland crossover

Grey’s Anatomy is currently in season 18, while Station 19 is in season 5. Both series come from creator Shonda Rhimes. And with Station 19 being a spinoff of Grey’s — plus the fact that they air back-to-back on ABC on Thursday nights — they’ve had some crossover events in the past. But this upcoming event looks to be a bit different. And the teaser has fans really excited.

“FINALLY a REAL crossover event that ACTUALLY needs to be watched on both shows! 👀🤯,” one fan shared in the video’s comments.

‘Grey’s Anatomy’ Showrunner Krista Vernoff promises a ‘pretty big event’ for episode 400

The upcoming crossover isn’t the only major event on the calendar for Grey’s Anatomy, though. The long-running series is getting close to episode 400, and showrunner Krista Vernoff is making plans for the milestone.

Unless there is an unexpected delay due to COVID or some crazy unforeseen circumstances, the landmark 400th episode will also be the Grey’s Anatomy season 18 finale that will air in May.

“It’s going to be a pretty big event, I think,” Vernoff told TVLine.

Krista Vernoff confirms there are still some ‘big ifs’

Vernoff admits that there are still some “big ifs” when it comes to airing episode 400. Filming was halted earlier in the year due to the Omicron variant. If production has to stop again for any reason, they might be forced to cut an episode from season 18. And if that happens, that would leave Grey’s Anatomy at episode 399 when the season comes to an end.

“I actually think that the last episode of our season will be 400, if there are no further COVID delays and we don’t end up dropping an episode,” the showrunner shared. “But that’s a big if.”

‘Grey’s Anatomy’ will be back for season 19

If they don’t make it to episode 400 this spring, that means that the season 19 premiere will end up serving as the series’ milestone. In January, ABC unexpectedly renewed Grey’s Anatomy for another season after Pompeo signed a new deal. At the time, Rhimes said she was excited for the story to continue.

“I couldn’t be more excited that we get to keep telling the stories of Meredith, Bailey, Richard, and all of the other doctors at Grey Sloan Memorial for another season,” Rhimes said, per Digital Spy.

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“This is a true testament to Krista, the cast, the crew and all the writers who keep the audience on the edge of their seat week after week. And it would not be possible without the generations of incredible fans who have supported Grey’s Anatomy for so many years.”

New episodes of Grey’s Anatomy and Station 19 air Thursday nights on ABC.